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San Francisco 49ers vs. Arizona Cardinals: Preview, Predictions and Picks for January 5, 2025

Updated on:
Jan 5, 2025 6:23 PM
On Sunday, January 5, 2025, at 4:25 PM, the San Francisco 49ers (6-10) will face off against the Arizona Cardinals (7-9) at State Farm Stadium in the season finale. The 49ers, led by QB Joshua Dobbs, look to improve their 2-5 road record, while the Cardinals aim to protect their 5-3 home record. This NFC West matchup promises to be an exciting conclusion to the season for both teams.
San Francisco 49ers vs Arizona Cardinals

Current Odds

SF
ARI
Over
60.5
-110
Under
69.5
-118
SF
+15.5
+160
ARI
-9.0
-130
SF
ML
+15000
ARI
ML
-200000

49ers vs Cardinals statistics

Stat 49ers Cardinals
Points Per Game 22.8 22.1
Total Yards 382.7 369.8
Yards Passing 256.1 226.1
Yards Rushing 126.6 143.8
Points Allowed Per Game 24.3 22.2
Yards Allowed 325.1 350.9
Pass Yards Allowed 202.1 225.3
Rush Yards Allowed 122.9 125.7

Arizona Cardinals recent games

Game Date Opponent Result Score
12/28/24 @ Los Angeles Rams L 13-9
12/22/24 @ Carolina Panthers L 36-30 OT
12/15/24 vs New England Patriots W 30-17
12/8/24 vs Seattle Seahawks L 30-18
12/1/24 @ Minnesota Vikings L 23-22

San Francisco 49ers recent games

Game Date Opponent Result Score
12/30/24 vs Detroit Lions L 40-34
12/22/24 @ Miami Dolphins L 29-17
12/12/24 vs Los Angeles Rams L 12-6
12/8/24 vs Chicago Bears W 38-13
12/1/24 @ Buffalo Bills L 35-10

Arizona Cardinals injuries

  • Jackson Barton (OT): Injured Reserve
  • Victor Dimukeje (LB): Questionable
  • Mack Wilson Sr. (LB): Questionable
  • Sean Murphy-Bunting (CB): Questionable
  • Michael Wilson (WR): Questionable

San Francisco 49ers injuries

  • Spencer Burford (OT): Injured Reserve
  • Demetrius Flannigan-Fowles (LB): Injured Reserve
  • Robert Beal Jr. (DE): Out
  • Isaac Yiadom (CB): Questionable
  • Ji'Ayir Brown (S): Questionable

49ers vs Cardinals game info

Type Info
Venue State Farm Stadium
Location Glendale, AZ
Kickoff Sun 4:25 PM
TV FOX
Temperature 67°
Chance of Rain 0%

49ers vs Cardinals predictions

As the San Francisco 49ers head into their matchup against the Arizona Cardinals, all eyes will be on Joshua Dobbs. He's expected to make quite the statement with around 207.9 passing yards, with a slightly optimistic prediction of adding 1.1 touchdowns to his name. Although a few interceptions may pepper his performance - pretty typical for a quarterback in his situation - it's Dobbs' rushing game that could surprise fans, anticipating around 28.9 rushing yards. Isaac Guerendo also enters the spotlight, projected to lead the ground attack with 64.0 rushing yards and a likely rushing touchdown. Pair this with Jauan Jennings—who's likely to be the target magnet racking up possibly 73.6 receiving yards—and you've got quite the offensive palette. Don't forget about George Kittle, either; his contributions are historically clutch and may tip the scales with a potential band of receptions and roughly an equal share in touchdown territory.

Looking at the Cardinals, Kyler Murray remains pivotal for Arizona, balancing his dual-threat game like a seasoned pro. His projected stats suggest he might dish out over 209.8 passing yards, threading one or two touchdown passes along the way. The nimbleness of his feet can't be ignored, pointing towards adding close to 39.3 rushing yards—a fascinating feat for any quarterback. Michael Carter is poised to hustle hard both on the ground and through the air, possibly amassing nearly 57.7 rushing yards and hovering close to 22.1 receiving yards. The time to shine could very well belong to Trey McBride as well, who figures to boast a solid performance with 61.7 receiving yards. It would be no surprise if his highlight reel gets another clip added this weekend.

With both teams bringing their unique flair to the field, predicting the winner feels like calling a near-even coin flip. The leverage might lean towards Arizona, considering the home turf at State Farm Stadium and their slightly better overall and conference records. There's something about the Cardinals' ability to clutch those crucial moments that could nudge them past, especially if Murray brings his A-game. Yet the 49ers aren't just rolling over; their underdog status could fuel unexpected outcomes. While it's anyone's game, this showdown holds the potential for the Cardinals to edge it out, especially with their knack for capitalizing on home advantage's comforts. What do you think—will home turf magic work for Arizona, or will the Niners surprise us all?

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