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St. Louis Cardinals vs. Atlanta Braves: Preview, Predictions and Picks for April 22, 2025

Updated on:
Apr 22, 2025 1:16 PM
The St. Louis Cardinals, seeking to snap a dismal 1-10 road record, head to Truist Park to take on the Atlanta Braves on Tuesday, April 22, 2025, at 7:15 PM. The Braves, who hold a 7-2 home record, will look to build on their early series lead after taking the first matchup. This interleague clash pits two struggling teams against each other, with both squads vying to climb out of their respective divisional cellar dwellings.
St. Louis Cardinals vs Atlanta Braves

Current Odds

STL
ATL
Over
8.5
-109
Under
8.5
+100
STL
+1.5
-153
ATL
-1.5
+149
STL
ML
+130
ATL
ML
-140

Cardinals vs Braves statistics

Stat Cardinals Braves
Hits 213 (2nd) 168 (Tied-18th)
Batting Average .264 (2nd) .232 (16th)
Runs Batted In 104 (Tied-6th) 81 (Tied-22nd)
Runs 109 (7th) 84 (Tied-23rd)
Home Runs 22 (Tied-18th) 29 (9th)
Walks 77 (13th) 76 (Tied-14th)
Stolen Bases 19 (Tied-14th) 13 (Tied-22nd)
Strikeouts 189 (16th) 205 (23rd)
Pitches 3530 (4th) 3231 (18th)

Atlanta Braves recent games

Game Date Opponent Result Score
4/21/25 vs St. Louis Cardinals W 7-6
4/20/25 vs Minnesota Twins W 6-2
4/19/25 vs Minnesota Twins W 4-3
4/18/25 vs Minnesota Twins W 6-4
4/16/25 @ Toronto Blue Jays L 3-1

St. Louis Cardinals recent games

Game Date Opponent Result Score
4/21/25 @ Atlanta Braves L 7-6
4/20/25 @ New York Mets L 7-4
4/19/25 @ New York Mets L 3-0
4/18/25 @ New York Mets L 5-4
4/17/25 @ New York Mets L 4-1

Atlanta Braves injuries

  • Nacho Alvarez Jr. (SS): 10-Day-IL
  • Spencer Strider (SP): 15-Day-IL
  • Ronald Acuna Jr. (RF): 10-Day-IL
  • Jurickson Profar (LF): suspension
  • Reynaldo Lopez (SP): 60-Day-IL

St. Louis Cardinals injuries

  • Masyn Winn (SS): 10-Day-IL
  • Nathan Church (LF): Day-To-Day
  • Quinn Mathews (SP): Day-To-Day
  • Drew Rom (SP): Day-To-Day
  • Ivan Herrera (C): 10-Day-IL

Cardinals vs Braves game info

Type Info
Venue Truist Park
Location Atlanta, Georgia
First pitch Tue 7:15 PM
Temperature 70°
Chance of Rain 47%

Cardinals vs Braves predictions

The St. Louis Cardinals are hitting the road with hopes of snapping their unfortunate stretch away from home. Taking center stage, Andre Pallante will try his best to command the mound. With an expected solid inning performance and respectable strikeout count, Pallante may just provide the stability the team desperately needs. At the plate, watch for Brendan Donovan, who's been swinging an impressive .356 average. Couple that with sneaky base hitting from Nolan Arenado, who’s also been clutch in driving in crucial runs, the Cardinals' offense seems poised to put the heat on Atlanta's pitching lineup. Willson Contreras adds the element of surprise, as he has consistently shown his ability to rack up extra-base hits. But let’s be honest, what would a Cardinals game be without a big hit from Nolan Gorman, especially if he continues making pitchers think twice with his home run potential?

Turning the lens towards the Atlanta Braves, it's hard to overlook players like Marcell Ozuna, whose batting average keeps the crowd on their toes. With Austin Riley bringing the heat with his consistency in racking up home runs, the Braves’ batting lineup becomes undeniably intimidating. Add to that the stealth of players like Ozzie Albies, who has a knack for connecting the ball with skill, making him a threat whenever he steps up to the plate. The Braves’ roster doesn't just rely on bats, their pitchers bring the magic too. If Dylan Lee gets a call to the mound, his strikeout prowess could potentially make key innings rough for the Cardinals. A lot of eyes will be on guys like Matt Olson and Sean Murphy, who are fitting pieces in Atlanta's strategic puzzle. Atlanta knows its strengths, and power hitting mixed with effective pitching can be a lethal combo.

So, who takes home the win? Considering the current form and home advantage at Truist Park, the odds seem to slightly favor the Atlanta Braves. The Braves' robust performers both at bat and on the mound come in stark contrast to the Cardinals' struggles on the road, where they've managed only one win out of eleven attempts. Meanwhile, Atlanta's home record showcases an impressive capacity to dominate within their turf. However, baseball fans know all too well that surprises are always lurking in the game. At the end of the day, the Braves might just stretch their series lead further. The Cardinals' underlying potential can't be ignored though, making this contest one for the books! Which team will clinch victory? Well, that remains up to the play-by-play action on the field.

Atlanta Braves

St. Louis Cardinals

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