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St. Louis Cardinals vs. Cincinnati Reds: Preview, Predictions and Picks for April 29, 2025

Updated on:
Apr 29, 2025 6:12 AM
The St. Louis Cardinals, struggling on the road with a 2-12 record, travel to Great American Ball Park to face the Cincinnati Reds, who lead the series 1-0 and are looking to build on their 16-13 overall record. The Reds, 7-6 at home, will aim to capitalize on the Cardinals' road woes and extend their series lead. This NL Central matchup promises to be an exciting clash on Tuesday, April 29, at 6:40 PM.
St. Louis Cardinals vs Cincinnati Reds

Current Odds

STL
CIN
Over
9.5
+100
Under
9.5
-100
STL
+1.0
-133
CIN
-1.5
+158
STL
ML
+119
CIN
ML
-122

Cardinals vs Reds statistics

Stat Cardinals Reds
Hits 264 (2nd) 250 (5th)
Batting Average .263 (2nd) .254 (6th)
Runs Batted In 124 (12th) 147 (3rd)
Runs 131 (12th) 153 (3rd)
Home Runs 24 (Tied-21st) 33 (Tied-10th)
Walks 102 (Tied-11th) 108 (9th)
Stolen Bases 23 (13th) 31 (7th)
Strikeouts 228 (11th) 247 (Tied-21st)
Pitches 4419 (4th) 4268 (14th)

Cincinnati Reds recent games

Game Date Opponent Result Score
4/28/25 vs St. Louis Cardinals W 3-1
4/27/25 @ Colorado Rockies W 8-1
4/26/25 @ Colorado Rockies W 6-4
4/25/25 @ Colorado Rockies W 8-7
4/23/25 @ Miami Marlins W 5-2

St. Louis Cardinals recent games

Game Date Opponent Result Score
4/28/25 @ Cincinnati Reds L 3-1
4/27/25 vs Milwaukee Brewers L 7-1
4/26/25 vs Milwaukee Brewers W 6-5
4/25/25 vs Milwaukee Brewers W 3-2
4/23/25 @ Atlanta Braves L 4-1

Cincinnati Reds injuries

  • Jake Fraley (RF): Day-To-Day
  • Sam Moll (RP): 15-Day-IL
  • Tyler Stephenson (C): 10-Day-IL
  • Christian Encarnacion-Strand (1B): 10-Day-IL
  • Carson Spiers (SP): 15-Day-IL

St. Louis Cardinals injuries

  • Quinn Mathews (SP): Day-To-Day
  • Drew Rom (SP): Day-To-Day
  • Ivan Herrera (C): 10-Day-IL
  • Zack Thompson (RP): 60-Day-IL
  • Victor Santos (RP): Day-To-Day

Cardinals vs Reds game info

Type Info
Venue Great American Ball Park
Location Cincinnati, Ohio
First pitch Tue 6:40 PM
Temperature 73°
Chance of Rain 51%

Cardinals vs Reds predictions

When the St. Louis Cardinals step onto the field against the Cincinnati Reds, they'll be looking to rebound from their current status in the NL Central. Keep an eye on Brendan Donovan, whose current batting average of .349 makes him a crucial component of their offensive strategy. Lars Nootbaar, delivering 17 RBIs so far, is another player who could potentially change the trajectory of the game with key hits. On the mound, Miles Mikolas will be tasked with keeping the Reds' bats quiet. His projections suggest he’ll be facing a challenging game but should be able to hold up, hopefully staying solid enough to outlast his opponent. Does Mikolas have what it takes today? Only time will tell.

Turning our gaze to the Cincinnati Reds, the home soil of the Great American Ball Park might just provide the edge they need to maintain their lead. This potential is headlined by Elly De La Cruz, who is looking to continue his impressive form. With an expected batting line of 1.3 hits per game and consistency in driving in runs, he’s crucial to the Reds' arsenal. Meanwhile, Austin Hays, known for his home-run prowess, is another player to watch. The stage is also set for Brady Singer, the Reds' probable starting pitcher, whose tricky movements and anticipated 4.3 strikeouts could spell trouble for the Cardinals' lineup. Can Singer outperform Mikolas from the Cardinals?

As the showdown looms, predicting a winner is no easy task. But looking at the little details, the Reds might have a slight advantage. Their slightly better record (16-13) and the home field atmosphere could work in their favor. Plus, with key players like De La Cruz and Hays in an upswing, the Reds seem well-positioned to clinch another win over St. Louis. Of course, in baseball, surprises are never off the table. Who knows what twists and turns await on the diamond? But if I had to pick, Cincinnati might just have that subtle edge to tip the scales and take this one home.

Cincinnati Reds

St. Louis Cardinals

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