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San Diego Padres vs. Detroit Tigers: Preview, Predictions and Picks for April 22, 2025

Updated on:
Apr 22, 2025 9:25 AM
The San Diego Padres, sitting second in the NL West with a 16-7 record, head to Comerica Park to face the first-place Detroit Tigers, who lead the series 1-0 after taking the opening game. The Tigers have been dominant at home, owning a 9-2 record, while the Padres have struggled on the road with a 4-6 mark. The two teams clash on Tuesday, April 22, at 6:40 PM in what promises to be an exciting matchup.
San Diego Padres vs Detroit Tigers

Current Odds

SD
DET
Over
7.5
+113
Under
7.5
-115
SD
-1.5
+166
DET
-1.5
+199
SD
ML
+100
DET
ML
-104

Padres vs Tigers statistics

Stat Padres Tigers
Hits 208 (3rd) 193 (Tied-8th)
Batting Average .274 (1st) .250 (10th)
Runs Batted In 92 (13th) 102 (8th)
Runs 101 (11th) 106 (10th)
Home Runs 23 (Tied-14th) 22 (Tied-18th)
Walks 81 (12th) 86 (8th)
Stolen Bases 25 (Tied-6th) 7 (29th)
Strikeouts 148 (1st) 211 (Tied-25th)
Pitches 3236 (17th) 3450 (7th)

Detroit Tigers recent games

Game Date Opponent Result Score
4/21/25 vs San Diego Padres W 6-4
4/20/25 vs Kansas City Royals L 4-3 F/10
4/19/25 vs Kansas City Royals W 3-1
4/18/25 vs Kansas City Royals W 7-3
4/17/25 vs Kansas City Royals W 6-1

San Diego Padres recent games

Game Date Opponent Result Score
4/21/25 @ Detroit Tigers L 6-4
4/20/25 @ Houston Astros W 3-2
4/19/25 @ Houston Astros L 3-2
4/18/25 @ Houston Astros L 6-4
4/16/25 vs Chicago Cubs W 4-2

Detroit Tigers injuries

  • Kerry Carpenter (LF): Day-To-Day
  • Brian Serven (C): Day-To-Day
  • Angel De Jesus (RP): Out
  • Manuel Margot (RF): 10-Day-IL
  • Matt Vierling (CF): 10-Day-IL

San Diego Padres injuries

  • Forrest Wall (LF): Day-To-Day
  • Francis Pena (RP): Out
  • Brandon Lockridge (CF): 10-Day-IL
  • Jason Heyward (LF): 10-Day-IL
  • Luis Arraez (1B): Out

Padres vs Tigers game info

Type Info
Venue Comerica Park
Location Detroit, Michigan
First pitch Tue 6:40 PM
Temperature 65°
Chance of Rain 0%

Padres vs Tigers predictions

The San Diego Padres are bringing some heavy hitters to the diamond for game two against the Detroit Tigers. Fernando Tatis Jr., batting an impressive .349, continues to be a standout. I wouldn’t be surprised to see him notch a couple of hits with his projected mix of singles, doubles, and possibly a home run as well. Keep an eye on Manny Machado too; he’s looking set to contribute significantly, possibly tallying up a couple of runs and RBIs. The Padres’ pitching ace for the day, Nick Pivetta, is likely to keep the Tigers on their toes with his remarkable strikeout potential. Putting all of this together, the Padres seem poised to bring some serious firepower to Comerica Park.

On the flip side, the Detroit Tigers have their own heavy hitters ready for action. Spencer Torkelson is one to watch, with a knack for smashing home runs. He's expected to be a key factor in the Tigers' offense alongside Kerry Carpenter, though Carpenter's current day-to-day status might slightly alter his participation. It’s worth noting that Carpenter, with his .315 batting average, has been one of their more reliable hitters when he's healthy. On the mound, Jack Flaherty will be looking to fend off the Padres’ lineup with a blend of solid innings and strikeouts. There’s something about how he commands the mound that might just keep the Tigers' defense feeling secure.

So, who do I think will walk away with the win in this one? It’s like weighing two equally tantalizing flavors—both teams have key players ready to make an impact. With both Tatis Jr. firing on all cylinders for the Padres and Torkelson looking solid for the Tigers, it might come down to who handles the pressure better at critical moments. While the Tigers have a slight edge at home given their strong record (9-2), this game could tip either way. Given the Padres' slightly better overall record and their formidable lineup, I'm leaning towards them to edge out a win. What do you think? Will the Tigers' home advantage prevail, or will the Padres’ offensive prowess seal the deal?

Detroit Tigers

San Diego Padres

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