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St. Louis Cardinals vs. Boston Red Sox: Preview, Predictions and Picks for April 6, 2025

Updated on:
Apr 6, 2025 6:07 PM
The St. Louis Cardinals travel to Fenway Park on Sunday, April 6, 2025, to take on the Boston Red Sox in the second game of their doubleheader. The Red Sox, currently 4-4 overall and 1-0 at home, look to build on their series lead, while the Cardinals aim to even the series after falling in the opener. The Cardinals, 4-3 overall and 0-1 on the road, will seek to secure their first away win of the season.
St. Louis Cardinals vs Boston Red Sox

Current Odds

STL
BOS
Over
9.5
+105
Under
9.5
-105
STL
+1.5
-172
BOS
-1.5
+165
STL
ML
+114
BOS
ML
-120

Cardinals vs Red Sox statistics

Stat Cardinals Red Sox
Hits 77 (Tied-7th) 71 (Tied-12th)
Batting Average .302 (1st) .256 (10th)
Runs Batted In 48 (Tied-4th) 38 (10th)
Runs 51 (4th) 40 (Tied-9th)
Home Runs 13 (5th) 9 (Tied-16th)
Walks 30 (Tied-11th) 33 (Tied-7th)
Stolen Bases 6 (17th) 11 (Tied-4th)
Strikeouts 55 (2nd) 78 (18th)
Pitches 1176 (21st) 1262 (13th)

Boston Red Sox recent games

Game Date Opponent Result Score
4/4/25 vs St. Louis Cardinals W 13-9
4/3/25 @ Baltimore Orioles W 8-4
4/2/25 @ Baltimore Orioles W 3-0
3/31/25 @ Baltimore Orioles L 8-5
3/30/25 @ Texas Rangers L 3-2

St. Louis Cardinals recent games

Game Date Opponent Result Score
4/4/25 @ Boston Red Sox L 13-9
4/2/25 vs Los Angeles Angels W 12-5
4/1/25 vs Los Angeles Angels L 9-7 F/11
3/31/25 vs Los Angeles Angels L 5-4 F/10
3/30/25 vs Minnesota Twins W 9-2

Boston Red Sox injuries

  • Brayan Bello (SP): 15-Day-IL
  • Liam Hendriks (RP): 15-Day-IL
  • Lucas Giolito (SP): 15-Day-IL
  • Matt Moore (RP): Day-To-Day
  • Masataka Yoshida (LF): 10-Day-IL

St. Louis Cardinals injuries

  • Zack Thompson (RP): 15-Day-IL
  • Nolan Gorman (2B): 10-Day-IL
  • Nathan Church (LF): Day-To-Day
  • Cooper Hjerpe (SP): Day-To-Day
  • Drew Rom (SP): Day-To-Day

Cardinals vs Red Sox game info

Type Info
Venue Fenway Park
Location Boston, Massachusetts
First pitch Sun 7:00 PM
TV ESPN
Temperature 51°
Chance of Rain 36%

Cardinals vs Red Sox predictions

The St. Louis Cardinals have a solid lineup heading into their game against the Boston Red Sox, and a few players to keep an eye on are the likes of Ivan Herrera and Lars Nootbaar. Herrera comes in with power at the plate, leading the team in home runs with four, and you can expect him to be a significant threat; I wouldn’t be surprised if he adds another homer to his tally. Nootbaar is also noteworthy, boasting an impressive .414 batting average, and his ability to reach base frequently will be crucial in putting pressure on the Red Sox. Adding to the mix, watch out for Brendan Donovan who seems poised to make an impact with his consistent ability to connect with the ball and get on base.

Switching over to the Boston Red Sox side of the diamond, the player to really watch is Wilyer Abreu. With a batting average of .500, Abreu is expected to be a key contributor, likely to grab a hit or two and maybe even crank another home run. Rafael Devers is another player to bet on for making noteworthy contributions in this game. Given his projections, Devers is likely to reach base at least a couple of times, potentially driving in some critical runs for Boston. Not to be forgotten, Jarren Duran is projected to be active on the bases and may even snag a stolen base if given the chance, which can turn the tables in crunch situations.

As for predictions, it’s anyone’s game at Fenway Park, but the vibe tilts slightly in favor of the Boston Red Sox. Having already taken a win in the first game of this doubleheader, the Sox have their spirits high and home-field advantage can never be underestimated. While both teams are closely matched in terms of records, there's just something about Boston's combination of batting depth and home support that might give them the edge they need to finish their day with another victory. Feel free to disagree, but this one could really be the Red Sox’s to lose.

Boston Red Sox

St. Louis Cardinals

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